Clomipramine-nortriptyline

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Clomipramine
Type Antidepressant
Group TCA
links
ATC-code N06AA04
Medscape Clomipramine
PubChem 2801
PubMed Clomipramine
Kompas (Dutch) Clomipramine
Wikipedia Clomipramine
Nortriptyline
Type Antidepressant
Group TCA
links
Medscape Nortriptyline
PubChem 4543
PubMed Nortriptyline
Kompas (Dutch) Nortriptyline
Wikipedia Nortriptyline

Switch medication from clomipramine to nortriptyline.[1] [2]

Nietinrijdenbord.png Stop clomipramine
  • Gradually reduce dosage of clomipramine to a maximum of 75 mg/day.
  • When a dosage of 75 mg/day is reached, stop administration.
Eenrichtingbord.png Start nortriptyline
  • No wash-out period is needed.
  • Start administration of nortriptyline the next day in a normal dosage of 25-50 mg/day.


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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