Clomipramine-nortriptyline
From Psychiatrienet
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Switch medication from clomipramine to nortriptyline.[1] [2]
Stop clomipramine - Gradually reduce dosage of clomipramine to a maximum of 75 mg/day.
- When a dosage of 75 mg/day is reached, stop administration.
Start nortriptyline- No wash-out period is needed.
- Start administration of nortriptyline the next day in a normal dosage of 25-50 mg/day.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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