Combining-Aripiprazole-Risperidone

Risperidone Type antipsychotic Group atypical AP Other use moodstabilizer links ATC-code N05AX08 Medscape Risperidone PubChem 5073 PubMed Risperidone Drugs.com risperidone Kompas (Dutch) Risperidone Wikipedia Risperidone more info DDD 5mg dose 0.25-4mg EQ-dosage 1 haloperidol T1/2 3h Tplasma 6h bioavailability 70% administration O

Ariprazole Type Antipsychotic Group Atypical AP Other use moodstabilizer links EMEA abilify PubChem 60975 PubMed Ariprazole Kompas (Dutch) Ariprazole Wikipedia Ariprazole more info

Adding aripiprazole to risperidone.

General information

• Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
• Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
• Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
• Risperidone is principally metabolized by CYP2D6 to an active metabolite.
• This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects.

Start aripiprazole

• Start aripiprazole according to the general dosing advice.

Cave

• Agents with anticholinergic properties may have additive effects when used in combination.

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