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Flupenthixol LA-Quetiapine

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Flupenthixol
long acting
Type Antipsychotic
Group Thioxanthenes
links
Medscape Flupenthixol
PubChem 17012
PubMed Flupenthixol
Kompas (Dutch) Flupenthixol
Wikipedia Flupenthixol
Quetiapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH04
Medscape Quetiapine
PubChem 5002
PubMed Quetiapine
Drugs.com quetiapine-fumarate
Kompas (Dutch) Quetiapine
Wikipedia Quetiapine

Switch medication from Flupenthixol_LA to Quetiapine.[5] [6]

Nietinrijdenbord.png Stop Flupenthixol_LA
  • Day 1: Last depot injection
Eenrichtingbord.png Start Quetiapine
  • Week 1-3: approx. 25% of target dose
  • Week 4-6: approx. 50% of target dose
  • Week 7-9: approx. 75% of target dose
  • Week 10: target dose
Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[7]
    StopDepotStartOral.jpg
Nietinrijdenbord.png — Flupenthixol_LA
Eenrichtingbord.png — Quetiapine


  1. 1.0 1.1 1.2 KNMP; Informatorium Medicamentorum 2023; Monografie "quetiapine" (Dutch)
  2. NVZA; Toxicology.org; Monografie 73 (dutch)
  3. Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
  4. Drugs.com quetiapine-fumarate
  5. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  6. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  7. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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