Switch medication from fluvoxamine to duloxetine.[1]
[2]
Stop fluvoxamine
- Before day 1: gradually reduce dosage of fluvoxamine to a maximum of 50 mg/day.
- Day 1: stop fluvoxamine.
Start duloxetine
- Day 5: start duloxetine 30 mg/day.
- Day 14: increase administration of duloxetine to 60 mg/day.
More information
- Fluvoxamine inhibits the metabolism of duloxetine through CYP1A2.
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop fluvoxamine 
Start duloxetine
More information