Switch medication from trazodone to duloxetine.[1]
[2]
Stop trazodone
- Before day 1: gradually reduce dosage of trazodone to a maximum of 100-150 mg/day, when this dosage is > 200 mg/day.
- Day 1: reduce dosage of trazodone to 75 mg or maintain on 100 mg/day.
- Day 8: stop administration of trazodone.
Start duloxetine
- A wash-out period is not necessary, but care is needed.
- Day 8: start administration of duloxetine in a normal dosage of 60 mg/day.
More information
- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- Duloxetine is a strong inhibitor of CYP2D6, which metabolizes trazodone.
- The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop trazodone 
Start duloxetine
More information