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Switch medication from mianserine to agomelatine.[1] [2]
Stop mianserine - Before day 1: gradually reduce dosage of mianserine to a maximum of 60 mg/day, when this dosage is > 60 mg/day.
- Day 1: reduce dosage of mianserine to 30 mg/day.
- Day 8: stop administration of mianserine.
Start agomelatine- Day 1: simultaneously start administration of agomelatine in a dosage of 25 mg/day.
- Day 8: only continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102
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