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Adding quetiapine to valproic acid.
General information- Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
- Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
Cave- During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. [6]
- ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
- ↑ Farmacotherapeutisch Kompas - valproinezuur (dutch)
- ↑ 3.0 3.1 3.2 3.3 KNMP; Informatorium Medicamentorum 2023; Monografie "valproaat" (Dutch)
Cite error: Invalid
<ref>tag; name "informatorium" defined multiple times with different content - ↑ NVZA; Toxicology.org; Monografie 73 (dutch)
- ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- ↑ 6.0 6.1 Drugs.com quetiapine-fumarate Cite error: Invalid
<ref>tag; name "drugscom" defined multiple times with different content
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