Metabolization is defined within this context as a property of a drug, and will be displayed on combination pages. Text
A
*Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
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*Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
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C
* Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
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G
* Gabapentin is eliminated unchanged by the kidney for 100%.
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L
* Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
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* Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
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O
* Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
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Q
* Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
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R
* Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
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T
* Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
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V
* Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
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Z
* Ziprasidone is metabolized by CYP1A2 (minor) and CYP3A4.
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