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Adding lamotrigine to topiramate.
General information- Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
- Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
- This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation will be recommended for this combination.
Start lamotrigine- Topiramate does not cause a significant change in lamotrigine levels. [4] Start topiramate according to the general dosing advice.
- ↑ 1.0 1.1 1.2 Farmacotherapeutisch Kompas - topiramaat (dutch)
Cite error: Invalid
<ref>tag; name "ftk" defined multiple times with different content - ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
- ↑ Drugs.com lamotrigine
- ↑ Berry at al, Lack of an effect of topiramate on lamotrigine serum concentrations. Epilepsia 2002;43(8):818-23
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