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Adding aripiprazole to gabapentin.
General information- Gabapentin is eliminated unchanged by the kidney for 100%.
- Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
- Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
- This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects. [2]
Start aripiprazole- Start aripiprazole according to the general dosing advice.
Cave- Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. [3]
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