Combining-Lithium-Aripiprazole

Lithium Type moodstabilizer Group other links ATC-code N05AN01 Medscape Lithium PubChem 11125 PubMed Lithium Drugs.com lithium Kompas (Dutch) Lithium Wikipedia Lithium more info T1/2 12-48h administration O

Ariprazole Type Antipsychotic Group Atypical AP Other use moodstabilizer links EMEA abilify PubChem 60975 PubMed Ariprazole Kompas (Dutch) Ariprazole Wikipedia Ariprazole more info

Adding aripiprazole to lithium.

General information

• Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
• Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
• This combination may have additive side effects.

Start aripiprazole

• Start aripiprazole according to the general dosing advice.

Cave

• The concomitant administration of lithium with neuroleptic agents may increase the risk of extrapyramidal reactions and neurotoxicity.

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