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Adding aripiprazole to topiramate.
General information- Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
- Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
- Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
- This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
Start aripiprazole- Start aripiprazole according general dosing advice.
Cave- Caution is advised when topiramate is prescribed with other drugs that predispose patients to heat-related disorders, including carbonic anhydrase inhibitors and drugs with anticholinergic activity. [2]
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