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Adding olanzapine to aripiprazole.
General information- Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
- Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
Start olanzapine- The combination of these 2 antipsychotics seems to be irrational from a pharmacotherapeutical point of view.
Cave- Agents with anticholinergic properties may have additive effects when used in combination. [4]
- ↑ 1.0 1.1 1.2 1.3 KNMP; Informatorium Medicamentorum 2023; Monografie "olanzapine" (Dutch)
- ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
- ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
- ↑ Interactions between aripiprazole and olanzapine on drugs.com
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