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Adding risperidone to aripiprazole.
General information- Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
- Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
Start risperidone- The combination of these 2 antipsychotics seems to be irrational from a pharmacotherapeutical point of view.
Cave- Agents with anticholinergic properties may have additive effects when used in combination.[4]
- ↑ 1.0 1.1 KNMP; Informatorium Medicamentorum 2023; Monografie "risperidon" (Dutch)
- ↑ Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- ↑ 3.0 3.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
- ↑ Interactions between risperidone and aripiprazole on drugs.com
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