{{ Drugswitch | from = vortioxetine | to = amitriptyline | stop =
- Day 1: stop administration of vortioxetine.
| start = No wash-out period is needed.
- Day 1: simultaneously start administration of amitriptyline in a dosage of 25 mg/day.
- Day 8: continue administration of amitriptyline in a dosage of 50 mg/day.
- Start low, go slow.