Switch medication from amitriptyline to clomipramine.[1]
[2]
Stop amitriptyline
- Gradually reduce dosage of amitriptyline to a maximum of 50-100 mg/day.
- When a dosage of 50 mg/day is reached, stop administration.
Start clomipramine
- No wash-out period is needed.
- Start administration of clomipramine the next day in a normal dosage of 50-75 mg/day.
More information
- Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.
- This switch is currently being reviewed.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop amitriptyline 
Start clomipramine
More information