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Switch medication from vortioxetine to amitriptyline.[1] [2]
Stop vortioxetine - Day 1: reduce dosage of vortioxetine to 5 mg/day.
- Day 8: stop administration of vortioxetine.
Start amitriptylineNo wash-out period is needed.
- Day 9: start administration of amitriptyline in a dosage of 25 mg/day.
- Day 16: continue administration of amitriptyline in a dosage of 50 mg/day.
- Day 22: bloodlevel vortioxetine is now zero, so you can increase faster.
More information- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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