Switch medication from moclobemide to tranylcypromine.[1]
[2]
Stop moclobemide
- Decrease with about 25% of original dose every 3 days
- Stop and wait for about 24 hour as a washout period
Start tranylcypromine
- Start tranylcypromine in a low dosage of 20 mg/day for one week.
- After this week the dosage of tranylcypromine can be increased.
More information
- Because of short halve life of moclobemide after stopping, the next antidepressant can start next day.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop moclobemide 
Start tranylcypromine
More information