Switching Antipsychotics
To see the consequences of a switch between antipsychotics click in the crosstable below:
the switch is made "from" (vertical) "to" (horizontal).
During switching: don't reduce dose of other anticholinergic drugs; consider adding oxazepam. Read: General considerations concerning switching antipsychotics.
Rest AP = Chlorprothixene, Flupentixol, Loxapine, Paliperidone, Pericyazine, Perphenazine,Promazine, Trifluoperazine, Zuclopentixol.
Partial agonist new = Aripiprazole, Brexpiprazole, Cariprazine.
| ↓ from | to → | Am | {{{afk02}}} | Cp | Hp | Lu | Ol | Pa | Pi | Qu | Rd | Sd | Sr | Zi | RA | Da | Df | Di | Dh | Do | Dp | Dr | Dz | Mz |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Am | Amisulpride | — | [[Amisulpride-{{{med02}}}|Am{{{afk02}}}]] | AmCp | AmHp | AmLu | AmOl | AmPa | AmPi | AmQu | AmRd | AmSd | AmSr | AmZi | AmRA | — | — | — | — | — | — | — | — | AmMz |
| {{{afk02}}} | [[{{{med02}}}-Amisulpride|{{{afk02}}}Am]] | — | [[{{{med02}}}-Clozapine|{{{afk02}}}Cp]] | [[{{{med02}}}-Haloperidol|{{{afk02}}}Hp]] | [[{{{med02}}}-Lurasidone|{{{afk02}}}Lu]] | [[{{{med02}}}-Olanzapine|{{{afk02}}}Ol]] | [[{{{med02}}}-Partial agonist|{{{afk02}}}Pa]] | [[{{{med02}}}-Pimozide|{{{afk02}}}Pi]] | [[{{{med02}}}-Quetiapine|{{{afk02}}}Qu]] | [[{{{med02}}}-Risperidone|{{{afk02}}}Rd]] | [[{{{med02}}}-Sertindole|{{{afk02}}}Sd]] | [[{{{med02}}}-Sulpiride|{{{afk02}}}Sr]] | [[{{{med02}}}-Ziprasidone|{{{afk02}}}Zi]] | [[{{{med02}}}-Rest AP|{{{afk02}}}RA]] | — | — | — | — | — | — | — | — | [[{{{med02}}}-Zuclopenthixol_MA|{{{afk02}}}Mz]] | |
| Cp | Clozapine | CpAm | [[Clozapine-{{{med02}}}|Cp{{{afk02}}}]] | — | CpHp | CpLu | CpOl | CpPa | CpPi | CpQu | CpRd | CpSd | CpSr | CpZi | CpRA | — | — | — | CpDh | — | — | — | — | CpMz |
| Hp | Haloperidol | HpAm | [[Haloperidol-{{{med02}}}|Hp{{{afk02}}}]] | HpCp | — | HpLu | HpOl | HpPa | HpPi | HpQu | HpRd | HpSd | HpSr | HpZi | HpRA | — | — | — | — | — | — | — | — | HpMz |
| Lu | Lurasidone | LuAm | [[Lurasidone-{{{med02}}}|Lu{{{afk02}}}]] | LuCp | LuHp | — | LuOl | LuPa | LuPi | LuQu | LuRd | LuSd | LuSr | LuZi | LuRA | — | — | — | — | LuDo | — | — | — | LuMz |
| Ol | Olanzapine | OlAm | [[Olanzapine-{{{med02}}}|Ol{{{afk02}}}]] | OlCp | OlHp | OlLu | — | OlPa | OlPi | OlQu | OlRd | OlSd | OlSr | OlZi | OlRA | — | — | — | — | — | OlDp | OlDr | — | OlMz |
| Pa | Partial agonist | PaAm | [[Partial agonist-{{{med02}}}|Pa{{{afk02}}}]] | PaCp | PaHp | PaLu | PaOl | PaPa | PaPi | PaQu | PaRd | PaSd | PaSr | PaZi | PaRA | PaDa | — | — | — | — | — | — | — | PaMz |
| Pi | Pimozide | PiAm | [[Pimozide-{{{med02}}}|Pi{{{afk02}}}]] | PiCp | PiHp | PiLu | PiOl | PiPa | — | PiQu | PiRd | PiSd | PiSr | PiZi | PiRA | — | — | — | — | — | — | — | — | PiMz |
| Qu | Quetiapine | QuAm | [[Quetiapine-{{{med02}}}|Qu{{{afk02}}}]] | QuCp | QuHp | QuLu | QuOl | QuPa | QuPi | — | QuRd | QuSd | QuSr | QuZi | QuRA | — | — | — | — | — | — | — | — | QuMz |
| Rd | Risperidone | RdAm | [[Risperidone-{{{med02}}}|Rd{{{afk02}}}]] | RdCp | RdHp | RdLu | RdOl | RdPa | RdPi | RdQu | — | RdSd | RdSr | RdZi | RdRA | — | — | — | — | — | — | — | — | RdMz |
| Sd | Sertindole | SdAm | [[Sertindole-{{{med02}}}|Sd{{{afk02}}}]] | SdCp | SdHp | SdLu | SdOl | SdPa | SdPi | SdQu | SdRd | — | SdSr | SdZi | SdRA | — | — | — | — | — | SdDp | SdDr | — | SdMz |
| Sr | Sulpiride | SrAm | [[Sulpiride-{{{med02}}}|Sr{{{afk02}}}]] | SrCp | SrHp | SrLu | SrOl | SrPa | SrPi | SrQu | SrRd | SrSd | — | SrZi | SrRA | — | — | — | — | — | — | — | — | SrMz |
| Zi | Ziprasidone | ZiAm | [[Ziprasidone-{{{med02}}}|Zi{{{afk02}}}]] | ZiCp | ZiHp | ZiLu | ZiOl | ZiPa | ZiPi | ZiQu | ZiRd | ZiSd | ZiSr | — | ZiRA | — | — | — | — | — | — | — | — | ZiMz |
| RA | Rest AP | RAAm | [[Rest AP-{{{med02}}}|RA{{{afk02}}}]] | RACp | RAHp | RALu | RAOl | RAPa | RAPi | RAQu | RARd | RASd | RASr | RAZi | RARA | — | RADf | RADi | — | — | — | — | RADz | RAMz |
| Da | Aripiprazole_LA | DaAm | [[Aripiprazole_LA-{{{med02}}}|Da{{{afk02}}}]] | DaCp | DaHp | DaLu | DaOl | DaPa | DaPi | DaQu | DaRd | DaSd | DaSr | DaZi | DaRA | — | — | — | — | — | — | — | — | DaMz |
| Df | Fluphenazine_LA | DfAm | [[Fluphenazine_LA-{{{med02}}}|Df{{{afk02}}}]] | DfCp | DfHp | DfLu | DfOl | DfPa | DfPi | DfQu | DfRd | DfSd | DfSr | DfZi | DfRA | — | — | — | — | — | — | — | — | DfMz |
| Di | Flupenthixol_LA | DiAm | [[Flupenthixol_LA-{{{med02}}}|Di{{{afk02}}}]] | DiCp | DiHp | DiLu | DiOl | DiPa | DiPi | DiQu | DiRd | DiSd | DiSr | DiZi | DiRA | — | — | — | — | — | — | — | — | DiMz |
| Dh | Haloperidol_LA | DhAm | [[Haloperidol_LA-{{{med02}}}|Dh{{{afk02}}}]] | DhCp | DhHp | DhLu | DhOl | DhPa | DhPi | DhQu | DhRd | DhSd | DhSr | DhZi | DhRA | — | — | — | — | — | — | — | — | DhMz |
| Do | Olanzapine_LA | DoAm | [[Olanzapine_LA-{{{med02}}}|Do{{{afk02}}}]] | DoCp | DoHp | DoLu | DoOl | DoPa | DoPi | DoQu | DoRd | DoSd | DoSr | DoZi | DoRA | — | — | — | — | — | — | — | — | DoMz |
| Dp | Paliperidone_LA | DpAm | [[Paliperidone_LA-{{{med02}}}|Dp{{{afk02}}}]] | DpCp | DpHp | DpLu | DpOl | DpPa | DpPi | DpQu | DpRd | DpSd | DpSr | DpZi | DpRA | — | — | — | — | — | DpDp | DpDr | — | DpMz |
| Dr | Risperidone_LA | DrAm | [[Risperidone_LA-{{{med02}}}|Dr{{{afk02}}}]] | DrCp | DrHp | DrLu | DrOl | DrPa | DrPi | DrQu | DrRd | DrSd | DrSr | DrZi | DrRA | — | — | — | — | — | DrDp | — | — | DrMz |
| Dz | Zuclopenthixol_LA | DzAm | [[Zuclopenthixol_LA-{{{med02}}}|Dz{{{afk02}}}]] | DzCp | DzHp | DzLu | DzOl | DzPa | DzPi | DzQu | DzRd | DzSd | DzSr | DzZi | DzRA | — | — | — | — | — | — | — | — | DzMz |
| Mz | Zuclopenthixol_MA | MzAm | [[Zuclopenthixol_MA-{{{med02}}}|Mz{{{afk02}}}]] | MzCp | MzHp | MzLu | MzOl | MzPa | MzPi | MzQu | MzRd | MzSd | MzSr | MzZi | MzRA | — | — | — | — | — | — | — | MzDz | — |
LA = long acting, MA = medium acting
(part of www.psychiatrienet.nl)