Switching Antipsychotics (part of www.psychiatrienet.nl)
To see the consequences of a switch between antipsychotics click in the crosstable below:
the switch is made "from" (vertical) "to" (horizontal).
During switching: don't reduce anticholinergics; consider adding oxazepam. Read: General considerations concerning switching antipsychotics.
Rest AP = Chlorprothixene, Flupentixol, Loxapine, Paliperidone, Pericyazine, Perphenazine,Promazine, Trifluoperazine, Zuclopentixol.
Partial antagonist new = Aripiprazole, Brexpiprazole, Cariprazine.
| ↓ from | to → | Am | Cp | Hp | Lu | Ol | Pa | Pi | Qu | Rd | Sd | Sr | Zi | RA | Da | Df | Di | Dh | Do | Dp | Dr | Dz | Mz | {{{afk23}}} |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Am | Amisulpride | — | AmCp | AmHp | AmLu | AmOl | AmPa | AmPi | AmQu | AmRd | AmSd | AmSr | AmZi | AmRA | AmDa | — | — | — | — | — | — | — | — | [[Amisulpride-{{{med23}}}|Am{{{afk23}}}]] |
| Cp | Clozapine | CpAm | — | CpHp | CpLu | CpOl | CpPa | CpPi | CpQu | CpRd | CpSd | CpSr | CpZi | CpRA | CpDa | — | — | — | — | — | — | — | — | [[Clozapine-{{{med23}}}|Cp{{{afk23}}}]] |
| Hp | Haloperidol | HpAm | HpCp | — | HpLu | HpOl | HpPa | HpPi | HpQu | HpRd | HpSd | HpSr | HpZi | HpRA | HpDa | — | — | — | HpDo | — | — | — | — | [[Haloperidol-{{{med23}}}|Hp{{{afk23}}}]] |
| Lu | Lurasidone | LuAm | LuCp | LuHp | — | LuOl | LuPa | LuPi | LuQu | LuRd | LuSd | LuSr | LuZi | LuRA | LuDa | — | — | — | — | — | — | — | — | [[Lurasidone-{{{med23}}}|Lu{{{afk23}}}]] |
| Ol | Olanzapine | OlAm | OlCp | OlHp | OlLu | — | OlPa | OlPi | OlQu | OlRd | OlSd | OlSr | OlZi | OlRA | OlDa | — | — | — | — | OlDp | — | — | — | [[Olanzapine-{{{med23}}}|Ol{{{afk23}}}]] |
| Pa | Partial agonist | PaAm | PaCp | PaHp | PaLu | PaOl | — | PaPi | PaQu | PaRd | PaSd | PaSr | PaZi | PaRA | PaDa | — | — | — | — | — | PaDr | PaDz | — | [[Partial agonist-{{{med23}}}|Pa{{{afk23}}}]] |
| Pi | Pimozide | PiAm | PiCp | PiHp | PiLu | PiOl | PiPa | PiPi | PiQu | PiRd | PiSd | PiSr | PiZi | PiRA | PiDa | PiDf | — | — | — | — | — | — | — | [[Pimozide-{{{med23}}}|Pi{{{afk23}}}]] |
| Qu | Quetiapine | QuAm | QuCp | QuHp | QuLu | QuOl | QuPa | QuPi | — | QuRd | QuSd | QuSr | QuZi | QuRA | QuDa | — | — | — | — | — | — | — | — | [[Quetiapine-{{{med23}}}|Qu{{{afk23}}}]] |
| Rd | Risperidone | RdAm | RdCp | RdHp | RdLu | RdOl | RdPa | RdPi | RdQu | — | RdSd | RdSr | RdZi | RdRA | RdDa | — | — | — | — | — | — | — | — | [[Risperidone-{{{med23}}}|Rd{{{afk23}}}]] |
| Sd | Sertindole | SdAm | SdCp | SdHp | SdLu | SdOl | SdPa | SdPi | SdQu | SdRd | — | SdSr | SdZi | SdRA | SdDa | — | — | — | — | — | — | — | — | [[Sertindole-{{{med23}}}|Sd{{{afk23}}}]] |
| Sr | Sulpiride | SrAm | SrCp | SrHp | SrLu | SrOl | SrPa | SrPi | SrQu | SrRd | SrSd | — | SrZi | SrRA | SrDa | — | — | — | — | — | SrDr | SrDz | — | [[Sulpiride-{{{med23}}}|Sr{{{afk23}}}]] |
| Zi | Ziprasidone | ZiAm | ZiCp | ZiHp | ZiLu | ZiOl | ZiPa | ZiPi | ZiQu | ZiRd | ZiSd | ZiSr | — | ZiRA | ZiDa | — | — | — | — | — | — | — | — | [[Ziprasidone-{{{med23}}}|Zi{{{afk23}}}]] |
| RA | Rest AP | RAAm | RACp | RAHp | RALu | RAOl | RAPa | RAPi | RAQu | RARd | RASd | RASr | RAZi | — | RADa | — | — | — | — | — | — | — | — | [[Rest AP-{{{med23}}}|RA{{{afk23}}}]] |
| Da | Aripiprazole_LA | DaAm | DaCp | DaHp | DaLu | DaOl | DaPa | DaPi | DaQu | DaRd | DaSd | DaSr | DaZi | DaRA | DaDa | — | DaDi | DaDh | — | — | — | — | DaMz | [[Aripiprazole_LA-{{{med23}}}|Da{{{afk23}}}]] |
| Df | Fluphenazine_LA | DfAm | DfCp | DfHp | DfLu | DfOl | DfPa | DfPi | DfQu | DfRd | DfSd | DfSr | DfZi | DfRA | DfDa | — | — | — | — | — | — | — | — | [[Fluphenazine_LA-{{{med23}}}|Df{{{afk23}}}]] |
| Di | Flupenthixol_LA | DiAm | DiCp | DiHp | DiLu | DiOl | DiPa | DiPi | DiQu | DiRd | DiSd | DiSr | DiZi | DiRA | DiDa | — | — | — | — | — | — | — | — | [[Flupenthixol_LA-{{{med23}}}|Di{{{afk23}}}]] |
| Dh | Haloperidol_LA | DhAm | DhCp | DhHp | DhLu | DhOl | DhPa | DhPi | DhQu | DhRd | DhSd | DhSr | DhZi | DhRA | DhDa | — | — | — | — | — | — | — | — | [[Haloperidol_LA-{{{med23}}}|Dh{{{afk23}}}]] |
| Do | Olanzapine_LA | DoAm | DoCp | DoHp | DoLu | DoOl | DoPa | DoPi | DoQu | DoRd | DoSd | DoSr | DoZi | DoRA | DoDa | — | — | — | — | — | — | — | — | [[Olanzapine_LA-{{{med23}}}|Do{{{afk23}}}]] |
| Dp | Paliperidone_LA | DpAm | DpCp | DpHp | DpLu | DpOl | DpPa | DpPi | DpQu | DpRd | DpSd | DpSr | DpZi | DpRA | DpDa | — | — | — | — | — | — | — | — | [[Paliperidone_LA-{{{med23}}}|Dp{{{afk23}}}]] |
| Dr | Risperidone_LA | DrAm | DrCp | DrHp | DrLu | DrOl | DrPa | DrPi | DrQu | DrRd | DrSd | DrSr | DrZi | DrRA | DrDa | — | — | — | — | — | DrDr | DrDz | — | [[Risperidone_LA-{{{med23}}}|Dr{{{afk23}}}]] |
| Dz | Zuclopenthixol_LA | DzAm | DzCp | DzHp | DzLu | DzOl | DzPa | DzPi | DzQu | DzRd | DzSd | DzSr | DzZi | DzRA | DzDa | — | — | — | — | — | DzDr | — | — | [[Zuclopenthixol_LA-{{{med23}}}|Dz{{{afk23}}}]] |
| Mz | Zuclopenthixol_MA | MzAm | MzCp | MzHp | MzLu | MzOl | MzPa | MzPi | MzQu | MzRd | MzSd | MzSr | MzZi | MzRA | MzDa | — | — | — | — | — | — | — | — | [[Zuclopenthixol_MA-{{{med23}}}|Mz{{{afk23}}}]] |
| {{{afk23}}} | [[{{{med23}}}-Amisulpride|{{{afk23}}}Am]] | [[{{{med23}}}-Clozapine|{{{afk23}}}Cp]] | [[{{{med23}}}-Haloperidol|{{{afk23}}}Hp]] | [[{{{med23}}}-Lurasidone|{{{afk23}}}Lu]] | [[{{{med23}}}-Olanzapine|{{{afk23}}}Ol]] | [[{{{med23}}}-Partial agonist|{{{afk23}}}Pa]] | [[{{{med23}}}-Pimozide|{{{afk23}}}Pi]] | [[{{{med23}}}-Quetiapine|{{{afk23}}}Qu]] | [[{{{med23}}}-Risperidone|{{{afk23}}}Rd]] | [[{{{med23}}}-Sertindole|{{{afk23}}}Sd]] | [[{{{med23}}}-Sulpiride|{{{afk23}}}Sr]] | [[{{{med23}}}-Ziprasidone|{{{afk23}}}Zi]] | [[{{{med23}}}-Rest AP|{{{afk23}}}RA]] | [[{{{med23}}}-Aripiprazole_LA|{{{afk23}}}Da]] | — | — | — | — | — | — | — | [[{{{med23}}}-Zuclopenthixol_MA|{{{afk23}}}Mz]] | — |
LA = long acting, MA = medium acting
(part of www.psychiatrienet.nl)