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Quetiapine-Zuclopenthixol MA

Quetiapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH04
Medscape Quetiapine
PubChem 5002
PubMed Quetiapine
Drugs.com quetiapine-fumarate
Kompas (Dutch) Quetiapine
Wikipedia Quetiapine
Zuclopenthixol
Medium long acting
Type Antipsychotic
Group Thioxanthenes
links
PubChem 5311507
PubMed Zuclopenthixol
Kompas (Dutch) Zuclopenthixol
Wikipedia Zuclopenthixol

Switch medication from Quetiapine to Zuclopenthixol_MA.[5] [6]

Nietinrijdenbord.png Stop Quetiapine
  • Stop or reduce drug, depending on symptomatology and (expected) adverse reactions.
  • The effects of both drugs will be superimposed for several days.
Eenrichtingbord.png Start Zuclopenthixol_MA
  • Day 1: Start drug according general dosing advice.
Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[7]
  • Zuclopenthixol_MA = Zuclopenthixol acetate [8]
  1. ↑ 1.0 1.1 1.2 KNMP; Informatorium Medicamentorum 2023; Monografie "quetiapine" (Dutch)
  2. ↑ NVZA; Toxicology.org; Monografie 73 (dutch)
  3. ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
  4. ↑ Drugs.com quetiapine-fumarate
  5. ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  6. ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  7. ↑ Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
  8. ↑ SPC Zuclopenthixol acetate
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