No wash-out period is needed. * '''Day 2:''' start administration of venlafaxine the next day in a low dosage of 37,.5 mg/day.* '''Day 229:''' increase dosage of venlafaxine to normal, 75 mg/day.* '''Day 29:''' gradually increase dosage of venlafaxine, if necessaryto 150 mg/day and more.| info = * Fluoxetine and norfluoxetine slow the metabolism of venlafaxine via CYP2D6.