* Administration '''Day 1-14:'''Gradually decrease the dosage of hypericum. * '''Day 15:''' stop administration of hypericum can be stopped abruptly.| start = * '''Day 115-730:''' a wash-out period of one week at least two weeks is necessary.* '''Day 831:''' start administration of imipramine in a dosage of 25-50 mg/day.* If necessary, increase dosage of imipramine to 50-75 mg/day.* Start low, go slow.

* Occurrence of the serotonin syndrome is possible without wash-out period.* Hypericum slows induces enzymes of the metabolism of imipramine via CYP3A4CYP P-450 type and P-gp. This effect may persist up to two weeks after stopping hypericum, so caution is necessary* Hypericum probably has MAO-inhibiting properties.}}