Changes

| start =

* '''Day 1-7:''' a wash-out period of one week is necessary.

* If necessary, increase dosage of imipramine to 50-75 mg/day.

* Start low, go slow.

| info =

* Hypericum slows the metabolism of imipramine via CYP3A4. This effect may persist up to two weeks after stopping hypericum, so caution is necessary.}}