* '''Day 115:''' simultaneously start administration of maprotiline in a low dosage of 25-75 mg/day.* '''Day 8:''' stop administration of venlafaxine and continue administration of maprotiline.

* “Start low, go slow” is not required, but caution with this switch is necessary. * Venlafaxine is a weak inhibitor of CYP2D6, which metabolizes maprotiline.}}