* '''Day 8-1422:''' a wash-out period of at least one week is necessary.* '''Day 1523:''' start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).| caveat = {{caveSS}}| info = {{HypericumInfo}}* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.* Hypericum slows the metabolism of sertraline via CYP3A4. }}