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* '''Day 8:''' stop administration of sertraline.
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* '''Day 8-1422:''' a wash-out period of at least one week is necessary.* '''Day 1523:''' start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).| caveat = {{caveSS}}| info = {{HypericumInfo}}* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.* Hypericum slows the metabolism of sertraline via CYP3A4. }}
