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* '''Day 4-7:''' reduce dosage of imipramine to 25 mg/day.
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* '''Day 14:''' simultaneously start administration of bupropion in a dosage of 150 mg/day and continue administration of imipramine according to the scheme above.
* '''Day 8:''' stop administration of imipramine and continue administration of bupropion.
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* Bupropion is a strong inhibitor of CYP2D6, which metabolizes imipramine.
}}