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* '''Before day 0:''' gradually reduce dosage of bupropion to a maximum of 60 mg/day.
* '''Day 1:''' reduce the dosage of duloxetine to 30 mg/day.
* '''Day 8:''' stop administration of duloxetine.
| start =
No wash-out period is needed.
* '''Day 18:''' simultaneously start administration of maprotiline in a low dosage of 25 mg/day.* '''Day 815:''' stop administration of duloxetine and increase the dosage of maprotiline to 50 mg/day.
| info =
* Duloxetine slows the metabolism of maprotiline by CYP2D6.