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* '''Day 1:''' reduce the dosage of duloxetine to 30 mg/day.
| start =
No wash-out period is needed.
* '''Day 1:''' simultaneously start administration of maprotiline in a low dosage of 25 mg/day.
* '''Day 8:''' stop administration of duloxetine and increase the dosage of maprotiline to 50 mg/day.
