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Created page with '{{Drugcombi | base = Topiramate | add = Carbamazepine | info = * Topiramate induces CYP3A4 and is an inhibiter of CYP2C19. * Carbamazepine is principally metabolized by CYP3A4 (...'
{{Drugcombi
| base = Topiramate
| add = Carbamazepine
| info =
* Topiramate induces CYP3A4 and is an inhibiter of CYP2C19.
* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
* This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation will be recommended for this combination.
| start =
* Carbamazepine can increase topiramate clearance. Add carbamazepine according to the general dosing advice and check the effects of topiramate and increase dose if necessary. <ref name=”medicatiebewaking”> Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002. </ref> <ref name=”bazire”> Bazire S, Pshychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007. </ref>
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}}
| base = Topiramate
| add = Carbamazepine
| info =
* Topiramate induces CYP3A4 and is an inhibiter of CYP2C19.
* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
* This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation will be recommended for this combination.
| start =
* Carbamazepine can increase topiramate clearance. Add carbamazepine according to the general dosing advice and check the effects of topiramate and increase dose if necessary. <ref name=”medicatiebewaking”> Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002. </ref> <ref name=”bazire”> Bazire S, Pshychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007. </ref>
| cave =
}}