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Fluoxetine-venlafaxine

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* Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day. * When a dosage of 20 mg/day is reached, stop administration.{{stopFluoxetine1}}

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No wash-out period is needed.

* '''Day 12:''' start venlafaxine the next day in low dosage of 37,5 mg/day.* '''Day 2122:''' increase dosage of venlafaxine to normal, 75 mg/day.* '''Day 2829:''' gradually increase dosage of venlafaxine, if necessary.

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* Fluoxetine has a very long elimination time; phasing out fluoxetine is therefore not necessary. {{longt1/2fluvox}}

* {{theorSS}}

* Fluoxetine and norfluoxetine inhibit de the metabolism of venlafaxine via CYP2D6.

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Fluoxetine-venlafaxine

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