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Combining-Olanzapine-Carbamazepine

212 bytes removed, 12:47, 21 April 2010
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| add = carbamazepine
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* Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
* This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation will be recommended for this combination.
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