387
edits
Changes
Created page with '{{Drugcombi | base = olanzapine | add = carbamazepine | info = * Olanzapine is principally metabolized by CYP1A2 and CYP2D6. * Carbamazepine is principally metabolized by CYP3A...'
{{Drugcombi
| base = olanzapine
| add = carbamazepine
| info =
* Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
* This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation will be recommended for this combination.
| start =
* Consider alternative for carbamazepine, otherwise start carbamazepine according to the general dosing advice.
* Check clinical effect or olanzapine plasma concentration after 2 weeks and adapt dose if necessary. <ref name=”medicatiebewaking”> Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002. </ref> <ref name=”bazire”> Bazire S, Psychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007. </ref>
| cave =
* Close clinical monitoring for evidence of altered olanzapine effect is recommended in patients receiving carbamazepine.
}}
| base = olanzapine
| add = carbamazepine
| info =
* Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
* This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation will be recommended for this combination.
| start =
* Consider alternative for carbamazepine, otherwise start carbamazepine according to the general dosing advice.
* Check clinical effect or olanzapine plasma concentration after 2 weeks and adapt dose if necessary. <ref name=”medicatiebewaking”> Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002. </ref> <ref name=”bazire”> Bazire S, Psychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007. </ref>
| cave =
* Close clinical monitoring for evidence of altered olanzapine effect is recommended in patients receiving carbamazepine.
}}
