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Combining-Topiramate-Carbamazepine

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* Topiramate induces CYP3A4 and is an inhibiter of CYP2C19.

* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.

* This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation will be recommended for this combination.

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Psychiatrienet β

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Combining-Topiramate-Carbamazepine

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