* Lithium and valproic acid are the most commonly used mood-stabilizing agents.<ref name="freeman">{{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref>

* The combination of lithium and valproate appears to be well tolerated and effective in treating bipolar illness.<ref name="freeman"/>

* This combination may be synergistic.<ref name="freeman"/>

* Lithium’s pharmacokinetics are not changed by valproate.<ref name="freeman"/>