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* Lithium and valproic acid are the most commonly used mood-stabilizing agents.<ref name="freeman">{{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref>
* The combination of lithium and valproate appears to be well tolerated and effective in treating bipolar illness.<ref name="freeman"/>
* Addition of lithium to valproic acid is the treatment of choice for acute mania with partial butinadequate response to valproate.<ref name="freeman"/>
* This combination may be synergistic.<ref name="freeman"/>
* Lithium’s pharmacokinetics are not changed by valproate.<ref name="freeman"/>
