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Duloxetine-vortioxetine

682 bytes removed, 14:13, 12 March 2015

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* '''Before day 1:''' gradually reduce dosage of duloxetine to a maximum of 60 mg/day, when this dosage is > 60 mg/day.

* '''Day 1-7:''' reduce dosage of duloxetine from 60 mg/day to 30 mg/day.* '''Day 8~~-14:''' reduce dosage of duloxetine to 30 mg/day to 0 mg/day~~* '''Day 15:''' stop ~~administration of~~ duloxetine.

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* A wash-out period of 3 days is ~~not necessary, but care is needed~~advisable.* '''Day 1511:''' Start administration of vortioxetine in a dosage of 10 mg/day.

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* Duloxetine is ~~a strong~~ an inhibitor of CYP2D6, which metabolizes vortioxetine.

* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.

* Patients could be directly switched from a SSRI or a SNRI to vortioxetine 10 mg/day. One week after initiation with vortioxetine, the dosage could be increased from 10 mg/day to 20 mg/day.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/25087600 Montgomery SA et al. A randomised, double-blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin reuptake inhibitor or serotonin-noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatine. Hum Psychopharmacol. 2014 Sep;29(5):470-82.]</ref>

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Walter

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Duloxetine-vortioxetine

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