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* '''Before day 1:''' gradually reduce dosage of duloxetine to a maximum of 60 mg/day, when this dosage is > 60 mg/day.
* '''Day 1-7:''' reduce dosage of duloxetine from 60 mg/day to 30 mg/day.* '''Day 8-14:''' reduce dosage of duloxetine to 30 mg/day to 0 mg/day* '''Day 15:''' stop administration of duloxetine.
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* A wash-out period of 3 days is not necessary, but care is neededadvisable.* '''Day 1511:''' Start administration of vortioxetine in a dosage of 10 mg/day.
| info =
* Duloxetine is a strong an inhibitor of CYP2D6, which metabolizes vortioxetine.
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
}}
