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* '''Day 1:''' reduce dosage of maprotiline to 50 mg/day.
* '''Day 8:''' reduce dosage of maprotiline to 25 mg/day.
* '''Day 1415:''' stop dosage of maprotiline.
| start =
* A wash-out period is not necessary.
* '''Day 15:''' start administration of vortioxetine in a dosage of 10 mg/day.
}}