[[File{{Drugswitch | from = maprotiline| to = vortioxetine | stop = | stop = * '''Before day 1:Empty''' gradually reduce dosage of maprotiline to a maximum of 75 mg/day.jpg]]* '''Day 1:''' reduce dosage of maprotiline to 50 mg/day.* '''Day 8:''' reduce dosage of maprotiline to 25 mg/day.* '''Day 14:''' stop dosage of maprotiline.| start = * A wash-out period is not necessary.* '''Day 15:''' start administration of vortioxetine in a dosage of 10 mg/day.}}