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* '''Day 48:''' simultaneously start administration of bupropion in a dosage of 150 mg/day and continue administration of doxepin according to the scheme above.* '''Day 815:''' stop administration of doxepin and continue administration of bupropion.* '''Day 1523:''' if necessary increase the dosage of bupropion.
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* Bupropion is a strong inhibitor of CYP2D6, which metabolizes doxepin.
* {{RiskSeizureBupropionTCA}}
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