* '''Before day 1:''' gradually reduce dosage of nortriptyline to a maximum of 100 mg/day.* '''Day 1:''' reduce dosage of nortriptyline to 50 mg/day.* '''Day 3:''' reduce dosage of nortriptyline to 25 mg/day.* '''Day 8:''' stop administration of nortriptyline.{{downNortriptyline}}
| start =
* A No wash-out period is not necessaryneeded.* '''Day 89:''' start administration of vortioxetine in a normal dosage of 10 mg/day.