* '''Before day 1:''' gradually reduce dosage of nortriptyline to a maximum of 100 mg/day.* '''Day 1:''' reduce dosage of nortriptyline to 50 mg/day.* '''Day 3:''' reduce dosage of nortriptyline to 25 mg/day.* '''Day 8:''' stop administration of nortriptyline.{{downNortriptyline}}
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* A No wash-out period is not necessaryneeded.* '''Day 89:''' start administration of vortioxetine in a normal dosage of 10 mg/day.
