{{stopVortioxetineTCAdecrease25p3d}}

* A wash'''Day 6 and after''': At approximately 50-out period 25% of 2 weeks is necessary, because the original vortioxetine dose start fluoxetine at 100% of CYP2D6-inhibitionthe target dose.* '''Day 23After 3 weeks:''' start administration If necessary, gradually increase dosage of fluoxetine in a normal dosage of 20 mg/day.

* {{theorSS}}Safe target dose fluoxetine = 20 mg* Fluoxetine is a strong inhibitor and norfluoxetine are inhibitors of CYP2D6(strong), which metabolizes vortioxetine. }}