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* '''Day 1:''' simultaneously start duloxetine in a low dosage of 30 mg/day.
* '''Day 8:''' stop administration of mianserine and only continue administration of duloxetinein a dosage of 60 mg/day.
* If necessary, increase the dosage of duloxetine.
| info =
* Caution with this switch is necessary, because duloxetine slows the metabolism of mianserine via CYP2D6. }}