Combining-Aripiprazole-Risperidone
From Psychiatrienet
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Adding aripiprazole to risperidone.
General information- Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
- Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
- Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
- Risperidone is principally metabolized by CYP2D6 to an active metabolite.
- This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects.
Start aripiprazole- Start aripiprazole according to the general dosing advice.
Cave- Agents with anticholinergic properties may have additive effects when used in combination.
- Interactions between risperidone and aripiprazole on drugs.com</ref>
- ↑ 1.0 1.1 KNMP; Informatorium Medicamentorum 2023; Monografie "risperidon" (Dutch)
- ↑ Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- ↑ 3.0 3.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
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