* '''Day 2: '''Start administration of imipramine the next day in a dosage of 25-75 mg/day.* If necessary, gradually increase dosage the dose with about 25% of the target dose every 3 days. * Therapeutic Drug Monitoring of imipramine to 150-200 mg/day under monitoring of bloodlevelis useful, especially during the build up phase. Blood sampling is possible when reaching a steady state with the same dose after one week.