Switch medication from agomelatine to imipramine.
- Day 1: Stop agomelatine.
- Agomelatine can be stopped abruptly for every dosage.
- Day 2: Start administration of imipramine in a dosage of 25-75 mg/day.
- If necessary, gradually increase the dose with about 25% of the target dose every 3 days under monitoring of bloodlevel.
- A wash-out period is not necessary.
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