Adding gabapentin to valproic acid.
- Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
- Gabapentin is eliminated unchanged by the kidney for 100%.
- Start gabapentin according to the general dosing advice.
- Farmacotherapeutisch Kompas; Toxicologie (dutch)
- Farmacotherapeutisch Kompas - valproinezuur (dutch)
Cite error: Invalid
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- KNMP; Informatorium Medicamentorum 2015; Monografie "valproaat" (Dutch)
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